Approved Projects - Canadian Longitudinal Study on Aging (CLSA)

Multi-organ functional ageing in the CLSA: Longitudinal phenotypes, omics, and mortality

We age in different ways. Some people lose strength or walking speed quickly; others...

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Multi-omics integrated analysis of obesity-related osteoarthritis

People who carry excess body weight have a much higher risk of developing osteoarthritis...

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Exploring the role of diet-induced premature immune aging on the development and prevention of early onset colorectal cancer

Colorectal cancer is the second leading cause of cancer-related death in Canada and is...

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Comparative evaluation of adiposity indices in predicting cardiometabolic multimorbidity: A prospective analysis from the Canadian Longitudinal Study on Aging

Obesity is a major risk factor for several chronic conditions, including diabetes, heart disease,...

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Associations between dietary patterns and menopausal health in middle-aged and older women: Findings from the CLSA: Study proposal

As women age, they experience unique health challenges related to menopause, including increased risks...

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Gender, social ties and diabetes in aging Canadians: A longitudinal study of diabetes-related depression and the mediation of nutrition factors

Diabetes and depression are major health challenges affecting millions of Canadians, especially older adults....

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Examining how individual- and area-level factors affect trajectories of healthy aging: An analysis of respondents from the Canadian Longitudinal Study on Aging

Healthy aging is a significant concern worldwide. Understanding the factors that affect it is...

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The utility of heart rate fragmentation to predict cognitive decline in the Canadian Longitudinal Study on Aging

The Alzheimer’s Society of Canada’s Landmark Study (2022) estimates that 1.7 million Canadians will...

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Predicting mobility limitations among older adults for developing preventative interventions

Pursuing an active lifestyle is vital for older adults’ quality of life and well-being....

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Informal or formal home care and rehabilitation utilization among aging Canadians with musculoskeletal conditions: A population-based study

Musculoskeletal disorders (MSKDs), such as arthritis and back pain, are leading causes of disability...

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Precision prediction of Alzheimer’s risk in women: Leveraging female-specific variables and machine learning for risk reduction

Alzheimer’s disease (AD) disproportionately affects women, yet most AD risk prediction models overlook female-specific...

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Development of a Healthy Aging Index (HAI) and exploring patterns of healthy aging trajectories using the Canadian Longitudinal Study on Aging

This project aims to develop a healthy aging index (HAI) based on a multidimensional...

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