Using metabolomics to examine the association between diet, inflammation, and frailty in the Canadian Longitudinal Study on Aging (CLSA)
Frailty is a condition where our bodies become less resilient and struggle to cope…
Learn MoreJune 3, 2026
Approved Projects
Find out how the CLSA research platform is being used.
Health deficit accumulation in relation to cardiovascular disease burden
Frailty in cardiovascular disease is a problem related to poor quality of life, hospital…
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Parkinson’s disease risk and phenoconversion: a polygenic risk score approach
Parkinson’s disease (PD) is a common neurodegenerative disease in older adults. Health conditions like…
Learn MorePublications
Read the latest peer-reviewed scientific publications.
Causal relationship of polyunsaturated fatty acids with mental disorders: a systematic review and meta-analysis
Yao Y, Yang X, Yan J, Lv H, Yue Z, Yu J, Lin X, Qian C, Zhang H, Liu Z, Ye M. Causal Relationship of Polyunsaturated Fatty Acids With Mental Disorders: A Systematic Review and Meta-analysis. Nutr Rev. 2026 May 8:nuaf225. doi: 10.1093/nutrit/nuaf225. Epub ahead of print. PMID: 42100925.
miR-221-3p-mediated CPT2 suppression links cardiomyocyte metabolic stress to NET-associated inflammation in myocardial ischemia-reperfusion injury: Multi-omics evidence and experimental validation
Mutailipu M, Aini A, Mutailifu D, Maimaitirexiti S, Maiwulanjiang M, Paerhati D, Maimaitiaili A. miR-221-3p-mediated CPT2 suppression links cardiomyocyte metabolic stress to NET-associated inflammation in myocardial ischemia-reperfusion injury: Multi-omics evidence and experimental validation. Int Immunopharmacol. 2026 Aug 10;187:117265. doi: 10.1016/j.intimp.2026.117265. Epub ahead of print. PMID: 42574811.
Genetically predicted plasma metabolites link the pathway from gut microbiome to Hashimoto’s thyroiditis
Yin Wang, Yuqian Luo. Genetically predicted plasma metabolites link the pathway from gut microbiome to Hashimoto’s thyroiditis. In Silico Research in Biomedicine, Volume 2. 2026. 100483. ISSN 3050-7871. doi:10.1016/j.insi.2026.100483.
Genetically predicted N-acetylisoleucine levels mediate the association between PB/PC% lymphocyte and normal pressure hydrocephalus: A mediation Mendelian randomization study
Liu C, Wang J, Yuan Y, Long P, Xiao G, Wang C. Genetically predicted N-acetylisoleucine levels mediate the association between PB/PC% lymphocyte and normal pressure hydrocephalus: A mediation Mendelian randomization study. Medicine (Baltimore). 2026 Jun 19;105(25):e49395. doi: 10.1097/MD.0000000000049395. PMID: 42332499; PMCID: PMC13286318.
Researcher Resources
Data collection, data access and data support documentation for researchers.
Researcher FAQs
Find answers to some of the most common queries about the CLSA.
Participant Resources
To ensure you are fully informed, this section provides links to information packages, consent forms and other documents relevant to your participation.
Participant FAQs
Find answers to some of the most common queries about the CLSA.
Webinar Recordings
All CLSA webinars are recorded and available on the CLSA website and CLSA YouTube channel.
