Multi-organ functional ageing in the CLSA: Longitudinal phenotypes, omics, and mortality

Project Summary

We age in different ways. Some people lose strength or walking speed quickly; others remain independent for years. Using data from the Canadian Longitudinal Study on Aging (CLSA), this project will track mobility (gait, balance, chair rise, grip), daily function (ADL/IADL), life-space (how far people move in daily life), bone and body composition (DXA), heart and vessel health (blood pressure, ECG, carotid thickness), blood tests, and molecular markers from blood (genetics, DNA methylation, and metabolites). We will map typical “patterns” of ageing, discover which factors predict decline or death, and build risk tools that combine clinical and molecular information. Results may help target prevention and rehabilitation to people most likely to benefit. Only de-identified data are used; no images or raw waveforms are requested.