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Canadian Longitudinal Study on Aging (CLSA)
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2025

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Migraine and its relationship to cognitive function, hormonal factors, vascular disease and dementia in an aging population, an analysis of the prospective cohort longitudinal CLSA study

It is unclear whether individuals with migraine experience greater cognitive decline or higher dementia...

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Subjective and biological aging: Examining the association between perceived healthy aging and epigenetic age acceleration in a Canadian cohort

This study investigates the association between biological aging (as estimated by DNA methylation) and...

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Development of an equitable AI screening tool for ophthalmic and systemic diseases using retinal imaging and longitudinal cohort data

Vision loss and chronic systemic diseases are major public health concerns, particularly as the...

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The epigenetics of chronic liver disease

Steatotic liver disease (SLD), previously known as fatty liver disease, is the most common...

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Multi-organ functional ageing in the CLSA: Longitudinal phenotypes, omics, and mortality

We age in different ways. Some people lose strength or walking speed quickly; others...

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Multi-omics integrated analysis of obesity-related osteoarthritis

People who carry excess body weight have a much higher risk of developing osteoarthritis...

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Exploring the role of diet-induced premature immune aging on the development and prevention of early onset colorectal cancer

Colorectal cancer is the second leading cause of cancer-related death in Canada and is...

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Comparative evaluation of adiposity indices in predicting cardiometabolic multimorbidity: A prospective analysis from the Canadian Longitudinal Study on Aging

Obesity is a major risk factor for several chronic conditions, including diabetes, heart disease,...

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Associations between dietary patterns and menopausal health in middle-aged and older women: Findings from the CLSA: Study proposal

As women age, they experience unique health challenges related to menopause, including increased risks...

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Gender, social ties and diabetes in aging Canadians: A longitudinal study of diabetes-related depression and the mediation of nutrition factors

Diabetes and depression are major health challenges affecting millions of Canadians, especially older adults....

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Examining how individual- and area-level factors affect trajectories of healthy aging: An analysis of respondents from the Canadian Longitudinal Study on Aging

Healthy aging is a significant concern worldwide. Understanding the factors that affect it is...

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The utility of heart rate fragmentation to predict cognitive decline in the Canadian Longitudinal Study on Aging

The Alzheimer’s Society of Canada’s Landmark Study (2022) estimates that 1.7 million Canadians will...

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