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Publications

Scientific publications using Canadian Longitudinal Study on Aging (CLSA) data.

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Associations and Interaction Effects of Socioeconomic, Lifestyle, and Genetic Factors on Intrinsic Capacity

Beyene MB, Visvanathan R, Alemu R, Theou O, Beben B, Cesari M, Beard J, Amare AT. Associations and Interaction Effects of Socioeconomic, Lifestyle, and Genetic Factors on Intrinsic Capacity. J Gerontol A Biol Sci Med Sci. 2026 Feb 23:glag057. doi: 10.1093/gerona/glag057. Epub ahead of print. PMID: 41729893.

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The Impact of a Prior Traumatic Brain Injury & Injury Characteristics on Frailty in the Canadian Longitudinal Study on Aging

Courish MK, O’Brien MW, Shivgulam ME, MacDonald EE, Mekari S, Theou O. The Impact of a Prior Traumatic Brain Injury & Injury Characteristics on Frailty in the Canadian Longitudinal Study on Aging. Arch Phys Med Rehabil. 2026 Jan 29:S0003-9993(26)00044-4. doi: 10.1016/j.apmr.2026.01.021. Epub ahead of print. PMID: 41620060.

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Associations Between Cognitive Risk Scores and Objective Cognition by Sexual Orientation: Evidence From the CLSA

Grady A, Stinchcombe A. Associations Between Cognitive Risk Scores and Objective Cognition by Sexual Orientation: Evidence From the CLSA. Res Aging. 2026 Jan 30:1640275261417696. doi: 10.1177/01640275261417696. Epub ahead of print. PMID: 41617141.

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The association between primary ovarian insufficiency and increased multimorbidity in a large prospective cohort (Canadian Longitudinal Study on Aging)

Kirubarajan A, Sohel N, Mayhew A, Griffith LE, Raina P, Shea AK. The association between primary ovarian insufficiency and increased multimorbidity in a large prospective cohort (Canadian Longitudinal Study on Aging). Fertil Steril. 2025 Feb;123(2):289-299. doi: 10.1016/j.fertnstert.2024.08.345. Epub 2024 Aug 29. PMID: 39216544.

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Changes in pneumococcal vaccine coverage in the Canadian Longitudinal Study on Aging (CLSA): An analysis based on the 2018-2021 follow-up 2 survey

Sulis G, Maredia N, Wolfson C, Basta NE. Changes in pneumococcal vaccine coverage in the Canadian Longitudinal Study on Aging (CLSA): An analysis based on the 2018-2021 follow-up 2 survey. PLoS One. 2026 Jan 23;21(1):e0338213. doi: 10.1371/journal.pone.0338213. PMID: 41576043; PMCID: PMC12829781.

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Pure tone auditory thresholds and their association with cognition in the Canadian Longitudinal Study on Aging

Wang YR, Bacon BA, Champoux F, Théoret H. Pure tone auditory thresholds and their association with cognition in the Canadian Longitudinal Study on Aging. Sci Rep. 2026 Jan 20. doi: 10.1038/s41598-026-36979-0. Epub ahead of print. PMID: 41559162.

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Genome-wide analysis of gene and air pollution interactions on COPD in the CLSA cohort

Odimba U, Farrell J, Sadatsafavi M, Jiang X, Gao Z. Genome-wide analysis of gene and air pollution interactions on COPD in the CLSA cohort. Environ Res. 2026 Jan 20:123837. doi: 10.1016/j.envres.2026.123837. Epub ahead of print. PMID: 41571064.

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What combinations of modifiable risk factors are most prevalent and most strongly associated with low cognition? – Results from Canadian Longitudinal Study on Aging

Son S, Speechley M, Zou G, Montero-Odasso M. What Combinations of Modifiable Risk Factors Are Most Prevalent and Most Strongly Associated with Low Cognition? Results from Canadian Longitudinal Study on Aging. Dement Geriatr Cogn Disord. 2026 Jan 20:1-13. doi: 10.1159/000550244. Epub ahead of print. PMID: 41557558.

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Causal associations between 1400 circulating metabolites and spontaneous abortion: A bidirectional 2-sample Mendelian randomization study

Zhou X, Fang YX, Zhang DW, Ma LY, Yao MM. Causal associations between 1400 circulating metabolites and spontaneous abortion: A bidirectional 2-sample Mendelian randomization study. Medicine (Baltimore). 2025 Nov 21;104(47):e45981. doi: 10.1097/MD.0000000000045981. PMID: 41305730; PMCID: PMC12643647.

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Role of metabolites in mediating the effect of gut microbiota on Crohn disease: A two-step Mendelian randomization (MR) study

Shi H, Peng Q. Role of metabolites in mediating the effect of gut microbiota on Crohn disease: A two-step Mendelian randomization (MR) study. Medicine (Baltimore). 2025 Nov 28;104(48):e46253. doi: 10.1097/MD.0000000000046253. PMID: 41327678; PMCID: PMC12662486.

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1400 plasma metabolites and Sjögren’s syndrome: a Mendelian randomization analysis

Cui Q, Zhou B, Feng Y, Huang Q. 1400 plasma metabolites and Sjögren’s syndrome: a Mendelian randomization analysis. Clin Rheumatol. 2025 Dec 3. doi: 10.1007/s10067-025-07799-w. Epub ahead of print. PMID: 41335288.

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Causal association of circulating metabolites with female infertility: a bidirectional mendelian randomization analysis

Liu L, Liu B, Liao M, Zeng B, Qin L, Li M. Causal association of circulating metabolites with female infertility: a bidirectional mendelian randomization analysis. Metabolomics. 2025 Oct 16;21(6):149. doi: 10.1007/s11306-025-02357-6. PMID: 41102584.

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Data Access

The CLSA data are currently available to approved public sector researchers in Canada and elsewhere. Learn more about eligibility and how to apply for access.

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