Vision and Eye Health

Han X, Gharahkhani P, Hamel AR, Ong JS, Rentería ME, Mehta P, Dong X, Pasutto F, Hammond C, Young TL, Hysi P, Lotery AJ, Jorgenson E, Choquet H, Hauser M, Cooke Bailey JN, Nakazawa T, Akiyama M, Shiga Y, Fuller ZL, Wang X, Hewitt AW, Craig JE, Pasquale LR, Mackey DA, Wiggs JL, Khawaja AP, Segrè AV; 23andMe Research Team; International Glaucoma Genetics Consortium; MacGregor S. Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci. Nat Genet. 2023 Jul;55(7):1116-1125. doi: 10.1038/s41588-023-01428-5. Epub 2023 Jun 29. PMID: 37386247.

Freeman EE, Bastasic J, Grant A, Leung G, Li G, Buhrmann R, Roy-Gagnon MH. Inverse Association of APOE ε4 and Glaucoma Modified by Systemic Hypertension: The Canadian Longitudinal Study on Aging. Invest Ophthalmol Vis Sci. 2022 Dec 1;63(13):9. doi: 10.1167/iovs.63.13.9. PMID: 36479943.

Phillips NA, Isler L, Kabir R, Hämäläinen A, Wittich W, Pichora-Fuller MK, Mick P. Hearing and visual acuity predict cognitive function in adults aged 45-85 years: Findings from the baseline wave of the Canadian Longitudinal Study on Aging (CLSA). Psychol Aging. 2022 Dec;37(8):891-912. doi: 10.1037/pag0000716. Epub 2022 Nov 10. PMID: 36355655.

Marshall H, Berry EC, Torres SD, Mullany S, Schmidt J, Thomson D, Nguyen TT, Knight LS, Hollitt G, Qassim A, Kolovos A, Ridge B, Schulz A, Lake S, Mills RA, Agar A, Galanopoulos A, Landers J, Healey PR, Graham SL, Hewitt AW, Casson RJ, MacGregor S, Siggs OM, Craig JE. Association Between Body Mass Index and Primary Open Angle Glaucoma in Three Cohorts. Am J Ophthalmol. 2023 Jan;245:126-133. doi: 10.1016/j.ajo.2022.08.006. Epub 2022 Aug 13. PMID: 35970205.

He W, Han X, Ong JS, Hewitt AW, Mackey DA, Gharahkhani P, MacGregor S; International Glaucoma Genetics Consortium. Association of Novel Loci With Keratoconus Susceptibility in a Multitrait Genome-Wide Association Study of the UK Biobank Database and Canadian Longitudinal Study on Aging. JAMA Ophthalmol. 2022 Jun 1;140(6):568-576. doi: 10.1001/jamaophthalmol.2022.0891. PMID: 35446358.

Corbin D, Lesage F. Assessment of the predictive potential of cognitive scores from retinal images and retinal fundus metadata via deep learning using the CLSA database. Sci Rep. 2022 Apr 6;12(1):5767. doi: 10.1038/s41598-022-09719-3. PMID: 35388080.

Grant A, Aubin MJ, Buhrmann R, Kergoat MJ, Li G, Freeman EE. Visual Impairment, Eye Disease, and 3-Year Cognitive Decline: The Canadian Longitudinal Study on Aging. Ophthalmic Epidemiol. 2022 Oct;29(5):545-553. doi: 10.1080/09286586.2021.1974494. Epub 2021 Sep 5. PMID: 34486480.

Grant A, Leung G, Aubin MJ, Kergoat MJ, Li G, Freeman EE. Fine Particulate Matter and Age-Related Eye Disease: The Canadian Longitudinal Study on Aging. Invest Ophthalmol Vis Sci. 2021 Aug 2;62(10):7. doi: 10.1167/iovs.62.10.7. PMID: 34369984.

Han X, Steven K, Qassim A, Marshall HN, Bean C, Tremeer M, An J, Siggs OM, Gharahkhani P, Craig JE, Hewitt AW, Trzaskowski M, MacGregor S. Automated AI labeling of optic nerve head enables insights into cross-ancestry glaucoma risk and genetic discovery in >280,000 images from UKB and CLSA. Am J Hum Genet. 2021 Jul 1;108(7):1204-1216. doi: 10.1016/j.ajhg.2021.05.005. Epub 2021 Jun 1. PMID: 34077762.

Kahiel Z, Grant A, Aubin MJ, Buhrmann R, Kergoat MJ, Freeman EE. Vision, Eye Disease, and the Onset of Balance Problems: The Canadian Longitudinal Study on Aging. Am J Ophthalmol. 2021 Nov;231:170-178. doi: 10.1016/j.ajo.2021.06.008. Epub 2021 Jun 23. PMID: 34157278.

Han X, Lee SS, Ingold N, McArdle N, Khawaja AP, MacGregor S, Mackey DA. Associations of sleep apnoea with glaucoma and age-related macular degeneration: an analysis in the United Kingdom Biobank and the Canadian Longitudinal Study on Aging. BMC Med. 2021 May 11;19(1):104. doi: 10.1186/s12916-021-01973-y. PMID: 33971878.

Hämäläinen A, Pichora-Fuller MK, Wittich W, Phillips NA, Mick P. Self-report Measures of Hearing and Vision in Older Adults Participating in the Canadian Longitudinal Study of Aging are Explained by Behavioral Sensory Measures, Demographic, and Social Factors. Ear Hear. 2021 July/Aug;42(4):814-831. doi: 10.1097/AUD.0000000000000992. PMID: 33741763.