Vision and Eye Health

Tran E, Rakesh M, Li G, Freeman EE, Roy-Gagnon MH. Does the Association Between Eye Disease and Cognitive Function Vary by Genetic Risk of Cognitive Decline? An Analysis of Hospital Data With Replication in the Canadian Longitudinal Study on Aging. Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):71. doi: 10.1167/iovs.66.6.71. PMID: 40548629; PMCID: PMC12186830.

Jiang X, Mahroo OA, Khawaja AP, Skowronska-Krawczyk D, Mackey DA, Wiggs JL, Hammond CJ, Hysi PG, Bell CG. Identification of blood-derived DNA methylation biomarkers of glaucoma and intraocular pressure measurements in three European ancestry cohorts including the Canadian longitudinal study on aging. Epigenetics. 2025 Dec;20(1):2566496. doi: 10.1080/15592294.2025.2566496. Epub 2025 Oct 17. PMID: 41105805; PMCID: PMC12536625.

O’Neil A, Welikala RA, Barman S, Owen CG, Rudnicka AR, Rakesh M, Roy-Gagnon MH, Maberley D, Freeman EE. Retinal Vessel Traits and Age-Related Eye Disease in the Canadian Longitudinal Study on Aging. Clin Exp Ophthalmol. 2025 Jun 14. doi: 10.1111/ceo.14566. Epub ahead of print. PMID: 40515626.

Lepetit-Aimon G, Mameri L, Duval R, Cheriet F. Enhanced Graph Representation for Reliable Retinal Vessel Analysis: CLSA Population-Based Study, 2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI), 2025, pp. 1-5, doi: 10.1109/ISBI60581.2025.10981176.

O’Neil A, Welikala RA, Barman S, Owen CG, Rudnicka AR, Rakesh M, Roy-Gagnon MH, Maberley D, Freeman EE. Factors Associated With Retinal Vessel Traits in the Canadian Longitudinal Study on Aging. Invest Ophthalmol Vis Sci. 2025 Mar 3;66(3):13. doi: 10.1167/iovs.66.3.13. PMID: 40048189; PMCID: PMC11895846.

Lelievre R, Rakesh M, Hysi PG, Little J, Freeman EE, Roy-Gagnon MH. Evaluating vitamin C-related gene-environment and metabolite-environment interaction effects on intraocular pressure in the Canadian Longitudinal Study on Aging. BMC Genom Data. 2025 Jan 29;26(1):10. doi: 10.1186/s12863-025-01301-w. PMID: 39881263; PMCID: PMC11776179.

Iverson E, Sukhai M, Quinn MP, Aubin MJ, Freeman EE. Visual impairment, employment status, and reduction in income: the Canadian Longitudinal Study on Aging. Can J Ophthalmol. 2024 May 23:S0008-4182(24)00131-5. doi: 10.1016/j.jcjo.2024.04.006. Epub ahead of print. PMID: 38797511.

Grant A, Roy-Gagnon MH, Bastasic J, Talekar A, Miller G, Li G, Freeman EE. Exploring ethnic and racial differences in intraocular pressure and glaucoma: The Canadian Longitudinal Study on aging. Heliyon. 2024 Mar 26;10(7):e28611. doi: 10.1016/j.heliyon.2024.e28611. PMID: 38586381; PMCID: PMC10998131.

He W, Han X, Ong JS, Wu Y, Hewitt AW, Mackey DA, Gharahkhani P, MacGregor S. Genome-wide meta-analysis identifies novel loci and improves disease prediction of age-related macular degeneration. Ophthalmology. 2023 Aug 25:S0161-6420(23)00622-X. doi: 10.1016/j.ophtha.2023.08.023. Epub ahead of print. PMID: 37634759.

Grant A, Roy-Gagnon MH, Bastasic J, Talekar A, Jessri M, Li G, Buhrmann R, Freeman EE. Alcohol Consumption, Genetic Risk, and Intraocular Pressure and Glaucoma: The Canadian Longitudinal Study on Aging. Invest Ophthalmol Vis Sci. 2023 Jul 3;64(10):3. doi: 10.1167/iovs.64.10.3. PMID: 37405759; PMCID: PMC10327959.

Han X, Gharahkhani P, Hamel AR, Ong JS, Rentería ME, Mehta P, Dong X, Pasutto F, Hammond C, Young TL, Hysi P, Lotery AJ, Jorgenson E, Choquet H, Hauser M, Cooke Bailey JN, Nakazawa T, Akiyama M, Shiga Y, Fuller ZL, Wang X, Hewitt AW, Craig JE, Pasquale LR, Mackey DA, Wiggs JL, Khawaja AP, Segrè AV; 23andMe Research Team; International Glaucoma Genetics Consortium; MacGregor S. Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci. Nat Genet. 2023 Jul;55(7):1116-1125. doi: 10.1038/s41588-023-01428-5. Epub 2023 Jun 29. PMID: 37386247.

Freeman EE, Bastasic J, Grant A, Leung G, Li G, Buhrmann R, Roy-Gagnon MH. Inverse Association of APOE ε4 and Glaucoma Modified by Systemic Hypertension: The Canadian Longitudinal Study on Aging. Invest Ophthalmol Vis Sci. 2022 Dec 1;63(13):9. doi: 10.1167/iovs.63.13.9. PMID: 36479943.