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Genome-wide meta-analysis

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Multi-omics integration reveals CYTL1 and H6PD as key regulators of tumor metabolism in mesothelioma

Ma J, Zhang H, Yu L, Guo Y, Ming J, Guo Z. Multi-omics integration reveals CYTL1 and H6PD as key regulators of tumor metabolism in mesothelioma. Genes Genomics. 2025 Oct;47(10):1049-1063. doi: 10.1007/s13258-025-01667-2. Epub 2025 Aug 25. PMID: 40853611.

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Dissecting Causal Relationships Between Gut Microbiota, Plasma Metabolites and Bladder Cancer: A Two-Step Mendelian Randomization Study

Che K, Qian D, Cui S, Xie F. Dissecting Causal Relationships Between Gut Microbiota, Plasma Metabolites and Bladder Cancer: A Two-Step Mendelian Randomization Study. Health Sci Rep. 2025 Sep 9;8(9):e71206. doi: 10.1002/hsr2.71206. PMID: 40937009; PMCID: PMC12420358.

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Genetically predicted plasma metabolites mediate the causal role of immune cells in atrial fibrillation

Yu Y, Krause K, Zarsteck S, Cao K, Lu S, Liu Y, Zhang J. Genetically predicted plasma metabolites mediate the causal role of immune cells in atrial fibrillation. Cytokine. 2025 Dec;196:157028. doi: 10.1016/j.cyto.2025.157028. Epub 2025 Sep 16. PMID: 40961544.

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Associations between 1400 metabolites and subtypes ofendometriosis: a two-sample Mendelian randomisation study

Yan F, Chen Z, Wu L, Huang Z. Associations between 1400 metabolites and subtypes of endometriosis: a two-sample Mendelian randomisation study. J Obstet Gynaecol. 2025 Dec;45(1):2552402. doi: 10.1080/01443615.2025.2552402. Epub 2025 Aug 28. PMID: 40874543.

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Genome-wide Cox regression analysis identifies 134 novel risk loci for disability development: the Canadian Longitudinal Study on Aging and UK Biobank

Zheng H, Sun T, Wang X. Genome-wide Cox regression analysis identifies 134 novel risk loci for disability development: the Canadian Longitudinal Study on Aging and UK Biobank. J Gerontol A Biol Sci Med Sci. 2025 Sep 19;80(10):glaf185. doi: 10.1093/gerona/glaf185. PMID: 40845153.

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Describing the profile of individuals at heightened risk for cardiometabolic multimorbidity: A secondary analysis of the Canadian Longitudinal Study on Aging data

Ketter NI, Jung M, Huot S, Sakakibara BM. Describing the Profile of Individuals at Heightened Risk for Cardiometabolic Multimorbidity: A Secondary Analysis of the Canadian Longitudinal Study on Aging Data. Am J Health Promot. 2025 Aug 29:8901171251374738. doi: 10.1177/08901171251374738. Epub ahead of print. PMID: 40882996.

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Genome-Wide Cox Regression Analysis Identifies 134 Novel Risk Loci for Disability Development: The Canadian Longitudinal Study on Aging and UK Biobank

Zheng H, Sun T, Wang X. Genome-Wide Cox Regression Analysis Identifies 134 Novel Risk Loci for Disability Development: The Canadian Longitudinal Study on Aging and UK Biobank. J Gerontol A Biol Sci Med Sci. 2025 Aug 22:glaf185. doi: 10.1093/gerona/glaf185. Epub ahead of print. PMID: 40845153.

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Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization

de Vries VA, Szabo A, Vergroesen JE, Liu S, van Garderen KA, Muthusamy K, Liskova P, Dudakova L, Khawaja AP, Tuft SJ, Klaver CCW, Davidson AE, Ramdas WD. Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization. Invest Ophthalmol Vis Sci. 2025 Jul 1;66(9):22. doi: 10.1167/iovs.66.9.22. PMID: 40626804; PMCID: PMC12248988.

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Causal relationships between immune-related adverse events, immune cell characteristics, and plasma metabolites: insights from Mendelian randomization study

Shi Z, Sun Z, Zhang D, Zhao L. Causal relationships between immune-related adverse events, immune cell characteristics, and plasma metabolites: insights from Mendelian randomization study. Discov Oncol. 2025 Jul 1;16(1):1210. doi: 10.1007/s12672-025-02607-y. PMID: 40591041; PMCID: PMC12214199.

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The effects of immune cells and blood metabolites on kidney stones: a bidirectional two-sample Mendelian randomization study and mediation analysis

Lin G, Wang L, Qiu J, Zhan F, Bu X, Wei W, Wang H. The effects of immune cells and blood metabolites on kidney stones: a bidirectional two-sample Mendelian randomization study and mediation analysis. Int Urol Nephrol. 2025 Jul 8. doi: 10.1007/s11255-025-04644-6. Epub ahead of print. PMID: 40629224.

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Elucidating the genetic and metabolomic underpinnings of age-related macular degeneration through two-sample Mendelian randomization

Shen W, Tan Y, Luo Z, Jin K, Ye J. Elucidating the genetic and metabolomic underpinnings of age-related macular degeneration through two-sample Mendelian randomization. Exp Eye Res. 2025 Sep;258:110491. doi: 10.1016/j.exer.2025.110491. Epub 2025 Jun 25. PMID: 40578594.

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Metabolic biomarkers mediate allergic rhinitis via circulating inflammatory proteins: Evidence from a Mendelian randomization study

Cao X, Zhang B, Wang W, Xu Z, Jiang Z. Metabolic biomarkers mediate allergic rhinitis via circulating inflammatory proteins: Evidence from a Mendelian randomization study. Braz J Otorhinolaryngol. 2025 Jun 25;91(5):101658. doi: 10.1016/j.bjorl.2025.101658. Epub ahead of print. PMID: 40570726; PMCID: PMC12246841.

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