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Genetics

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Metabolic gene function discovery platform GeneMAP identifies SLC25A48 as necessary for mitochondrial choline import

Khan A, Unlu G, Lin P, Liu Y, Kilic E, Kenny TC, Birsoy K, Gamazon ER. Metabolic gene function discovery platform GeneMAP identifies SLC25A48 as necessary for mitochondrial choline import. Nat Genet. 2024 Jul 8. doi: 10.1038/s41588-024-01827-2. Epub ahead of print. PMID: 38977856.

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Causal relationships of gut microbiota, plasma metabolites, and metabolite ratios with diffuse large B-cell lymphoma: a Mendelian randomization study

Qian J, Zheng W, Fang J, Cheng S, Zhang Y, Zhuang X, Song C. Causal relationships of gut microbiota, plasma metabolites, and metabolite ratios with diffuse large B-cell lymphoma: a Mendelian randomization study. Front Microbiol. 2024 May 27;15:1356437. doi: 10.3389/fmicb.2024.1356437. PMID: 38860219; PMCID: PMC11163048.

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Exploring the Mediation Effect of Metabolite Levels on the Association Between Gut Microbiota and HCC: A two-step, two-sample bidirectional Mendelian Randomization

Xu B, Zhu L, Hu P, Yao W, Ke M, Zhu Z. Exploring the Mediation Effect of Metabolite Levels on the Association Between Gut Microbiota and HCC: A two-step, two-sample bidirectional Mendelian Randomization. J Cancer. 2024 May 30;15(12):3975-3983. doi: 10.7150/jca.96579. PMID: 38911378; PMCID: PMC11190768.

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Effect modification by sex of genetic associations of vitamin C related metabolites in the Canadian Longitudinal study on aging

Lelievre R, Rakesh M, Hysi PG, Little J, Freeman EE, Roy-Gagnon MH. Effect modification by sex of genetic associations of vitamin C related metabolites in the Canadian Longitudinal study on aging. Front Genet. 2024 Jul 31;15:1411931. doi: 10.3389/fgene.2024.1411931. PMID: 39144724; PMCID: PMC11322087.

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Role of metabolites in mediating the effect of triacylglycerol on aplastic anemia

Zhu J, Li W. Role of metabolites in mediating the effect of triacylglycerol on aplastic anemia. Hematology. 2024 Dec;29(1):2379178. doi: 10.1080/16078454.2024.2379178. Epub 2024 Jul 17. PMID: 39017035.

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Associations between serum metabolites and female cancers: A bidirectional two-sample mendelian randomization study

Cao Z, Long X, Yuan L. Associations between Serum Metabolites and Female Cancers: a Bidirectional Two-sample Mendelian Randomization Study. J Steroid Biochem Mol Biol. 2024 Jul 12:106584. doi: 10.1016/j.jsbmb.2024.106584. Epub ahead of print. PMID: 39004376.

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Metabolomic insights into pulmonary fibrosis: a mendelian randomization study

Tang W, Jiang H, Wu X, Wu G, Zhao C, Lin W, Zhu Y, Jiang G, Chen X, Huang H, He L. Metabolomic insights into pulmonary fibrosis: a mendelian randomization study. BMC Pulm Med. 2024 Jun 6;24(1):271. doi: 10.1186/s12890-024-03079-6. PMID: 38844923; PMCID: PMC11155030.

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Inflammatory proteins mediate male erectile dysfunction via plasma metabolites 

Kang Z, Zhang ZR, Feng ZY, Dong LS, Yang J. Inflammatory proteins mediate male erectile dysfunction via plasma metabolites. Sex Med. 2024 May 31;12(3):qfae027. doi: 10.1093/sexmed/qfae027. PMID: 38827362; PMCID: PMC11140220.

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Exploring the Mediation Effect of Metabolite Levels on the Association Between Gut Microbiota and HCC: A two-step, two-sample bidirectional Mendelian Randomization

Xu B, Zhu L, Hu P, Yao W, Ke M, Zhu Z. Exploring the Mediation Effect of Metabolite Levels on the Association Between Gut Microbiota and HCC: A two-step, two-sample bidirectional Mendelian Randomization. J Cancer. 2024 May 30;15(12):3975-3983. doi: 10.7150/jca.96579. PMID: 38911378; PMCID: PMC11190768.

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Blood metabolites and chronic kidney disease: a Mendelian randomization study

Hou Y, Xiao Z, Zhu Y, Li Y, Liu Q, Wang Z. Blood metabolites and chronic kidney disease: a Mendelian randomization study. BMC Med Genomics. 2024. May 20 2024;17:147. doi: 10.1186/s12920-024-01918-3.

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Causal relationships of gut microbiota, plasma metabolites, and metabolite ratios with diffuse large B-cell lymphoma: a Mendelian randomization study

Qian J, Zheng W, Fang J, Cheng S, Zhang Y, Zhuang X, Song C. Causal relationships of gut microbiota, plasma metabolites, and metabolite ratios with diffuse large B-cell lymphoma: a Mendelian randomization study. Front Microbiol. 2024 May 27;15:1356437. doi: 10.3389/fmicb.2024.1356437. PMID: 38860219; PMCID: PMC11163048.

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Polygenic Prediction of Keratoconus and its Measures: Cross-Sectional and Longitudinal Analyses in Community-Based Young Adults

Lee SS, Diaz-Torres S, He W, Yazar S, Chan E, Chong EW, Gharahkhani P, Macgregor S, Lingham G, Mackey DA. Polygenic Prediction of Keratoconus and its Measures: Cross-Sectional and Longitudinal Analyses in Community-Based Young Adults. Am J Ophthalmol. 2024 May 11;265:248-256. doi: 10.1016/j.ajo.2024.05.009. Epub ahead of print. PMID: 38740237.

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