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Genetics

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Unlocking the Secrets: Causal Associations Between Blood Metabolites and Aspergillosis

Ma Y, Du W. Unlocking the Secrets: Causal Associations Between Blood Metabolites and Aspergillosis. Curr Microbiol. 2025 Sep 4;82(10):490. doi: 10.1007/s00284-025-04465-x. PMID: 40906222.

Mendelian randomisation analysis to discover plasma metabolites mediating the effect of obesity on cancer risk

Yates T, Went M, Mills C, Law P, Gockel I, Maj C, Schumacher J, Palles C, Houlston R. Mendelian randomisation analysis to discover plasma metabolites mediating the effect of obesity on cancer risk. Br J Cancer. 2025 Nov;133(9):1344-1353. doi: 10.1038/s41416-025-03170-7. Epub 2025 Sep 2. PMID: 40897820; PMCID: PMC12572173.

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Investigating Causal Links between Metabolite Profiles and Ulcerative Colitis: A Bidirectional Mendelian Randomization Study

Zarei P, Kamali Z, Keshteli AH, Sedeh PA, Vaez A. Investigating Causal Links between Metabolite Profiles and Ulcerative Colitis: A Bidirectional Mendelian Randomization Study. J Med Signals Sens. 2025 Sep 1;15:27. doi: 10.4103/jmss.jmss_16_25. PMID: 40949582; PMCID: PMC12431707.

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Plasma metabolites mediate the effects of circulating immune cell phenotypes on prostate cancer: A 2-step Mendelian randomization study

Zhou W, Ding J, Shen Y, Huang F, Xu D. Plasma metabolites mediate the effects of circulating immune cell phenotypes on prostate cancer: A 2-step Mendelian randomization study. Medicine (Baltimore). 2025 Sep 5;104(36):e44282. doi: 10.1097/MD.0000000000044282. PMID: 40922267; PMCID: PMC12419313.

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Multi-omics integration reveals CYTL1 and H6PD as key regulators of tumor metabolism in mesothelioma

Ma J, Zhang H, Yu L, Guo Y, Ming J, Guo Z. Multi-omics integration reveals CYTL1 and H6PD as key regulators of tumor metabolism in mesothelioma. Genes Genomics. 2025 Oct;47(10):1049-1063. doi: 10.1007/s13258-025-01667-2. Epub 2025 Aug 25. PMID: 40853611.

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Dissecting Causal Relationships Between Gut Microbiota, Plasma Metabolites and Bladder Cancer: A Two-Step Mendelian Randomization Study

Che K, Qian D, Cui S, Xie F. Dissecting Causal Relationships Between Gut Microbiota, Plasma Metabolites and Bladder Cancer: A Two-Step Mendelian Randomization Study. Health Sci Rep. 2025 Sep 9;8(9):e71206. doi: 10.1002/hsr2.71206. PMID: 40937009; PMCID: PMC12420358.

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Genetically predicted plasma metabolites mediate the causal role of immune cells in atrial fibrillation

Yu Y, Krause K, Zarsteck S, Cao K, Lu S, Liu Y, Zhang J. Genetically predicted plasma metabolites mediate the causal role of immune cells in atrial fibrillation. Cytokine. 2025 Dec;196:157028. doi: 10.1016/j.cyto.2025.157028. Epub 2025 Sep 16. PMID: 40961544.

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Associations between 1400 metabolites and subtypes ofendometriosis: a two-sample Mendelian randomisation study

Yan F, Chen Z, Wu L, Huang Z. Associations between 1400 metabolites and subtypes of endometriosis: a two-sample Mendelian randomisation study. J Obstet Gynaecol. 2025 Dec;45(1):2552402. doi: 10.1080/01443615.2025.2552402. Epub 2025 Aug 28. PMID: 40874543.

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Genome-wide Cox regression analysis identifies 134 novel risk loci for disability development: the Canadian Longitudinal Study on Aging and UK Biobank

Zheng H, Sun T, Wang X. Genome-wide Cox regression analysis identifies 134 novel risk loci for disability development: the Canadian Longitudinal Study on Aging and UK Biobank. J Gerontol A Biol Sci Med Sci. 2025 Sep 19;80(10):glaf185. doi: 10.1093/gerona/glaf185. PMID: 40845153.

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Describing the profile of individuals at heightened risk for cardiometabolic multimorbidity: A secondary analysis of the Canadian Longitudinal Study on Aging data

Ketter NI, Jung M, Huot S, Sakakibara BM. Describing the Profile of Individuals at Heightened Risk for Cardiometabolic Multimorbidity: A Secondary Analysis of the Canadian Longitudinal Study on Aging Data. Am J Health Promot. 2025 Aug 29:8901171251374738. doi: 10.1177/08901171251374738. Epub ahead of print. PMID: 40882996.

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Genome-Wide Cox Regression Analysis Identifies 134 Novel Risk Loci for Disability Development: The Canadian Longitudinal Study on Aging and UK Biobank

Zheng H, Sun T, Wang X. Genome-Wide Cox Regression Analysis Identifies 134 Novel Risk Loci for Disability Development: The Canadian Longitudinal Study on Aging and UK Biobank. J Gerontol A Biol Sci Med Sci. 2025 Aug 22:glaf185. doi: 10.1093/gerona/glaf185. Epub ahead of print. PMID: 40845153.

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Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization

de Vries VA, Szabo A, Vergroesen JE, Liu S, van Garderen KA, Muthusamy K, Liskova P, Dudakova L, Khawaja AP, Tuft SJ, Klaver CCW, Davidson AE, Ramdas WD. Decoding the Cornea-Glaucoma Association: Evidence From Mendelian Randomization. Invest Ophthalmol Vis Sci. 2025 Jul 1;66(9):22. doi: 10.1167/iovs.66.9.22. PMID: 40626804; PMCID: PMC12248988.

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