Fragilité

Halliwell C, Moyer R, Legge A, Theou O, Bélanger M, Mekari S, O’Brien MW. Frailty is associated with lower-limb osteoarthritis incidence over six-years regardless of sex and type of frailty index in the Canadian longitudinal study on aging. Osteoarthr Cartil Open. 2026 May 27;8(3):100827. doi: 10.1016/j.ocarto.2026.100827. PMID: 42283064; PMCID: PMC13251491.

Mehrabi F, Phillips NA, Pichora-Fuller MK, Wittich W, Andrew MK, Mick P. Frailty Progression Moderates the Association Between Sensory and Cognitive Trajectories Over 6 Years: Evidence From the Canadian Longitudinal Study on Aging. Ear Hear. 2026 Jun 1. doi: 10.1097/AUD.0000000000001839. Epub ahead of print. PMID: 42223330.

Courish MK, O’Brien MW, Shivgulam ME, MacDonald EE, Mekari S, Theou O. The Impact of a Prior Traumatic Brain Injury and Injury Characteristics on Frailty in the Canadian Longitudinal Study on Aging. Arch Phys Med Rehabil. 2026 Jun;107(6):1322-1329. doi: 10.1016/j.apmr.2026.01.021. Epub 2026 Jan 29. PMID: 41620060.

Rafiq T, Ma J, Joshi D, Mayhew A, Griffith L, van den Heuvel E, Raina P. Dietary metabolomic determinants of frailty through inflammation in the Canadian Longitudinal Study on Aging. NPJ Aging. 2026 Mar 23. doi: 10.1038/s41514-026-00367-9. Epub ahead of print. PMID: 41872230.

Courish MK, O’Brien MW, Shivgulam ME, MacDonald EE, Mekari S, Theou O. The Impact of a Prior Traumatic Brain Injury & Injury Characteristics on Frailty in the Canadian Longitudinal Study on Aging. Arch Phys Med Rehabil. 2026 Jan 29:S0003-9993(26)00044-4. doi: 10.1016/j.apmr.2026.01.021. Epub ahead of print. PMID: 41620060.

Griffith LE, Terrera GM, van den Heuvel E, Khattar J, Hogan DB, O’Connell M, Levasseur M, Raina P. Physical, Psychological, Cognitive and Social Frailty Domains in Community-Dwelling Adults Aged 45-85: a Cross-sectional Analysis of the Canadian Longitudinal Study on Aging (CLSA). Can Geriatr J. 2025 Dec 3;28(4):343-352. doi: 10.5770/cgj.28.872. PMID: 41306637; PMCID: PMC12646700.

Duignan L, Dutton D. Comprehensiveness vs Efficiency: A Cross-Sectional Analysis of the Association Between Allostatic Load and the Frailty Index Using the CLSA. J Am Med Dir Assoc. 2025 Sep 8;26(11):105829. doi: 10.1016/j.jamda.2025.105829. Epub ahead of print. PMID: 40882950.

Lavecchia M, Marucci M, Raina P, Jimenez W, Nguyen JMV. Frailty and gynecologic cancer: a cross-sectional analysis of the Canadian Longitudinal Study on Aging. International Journal of Gynecological Cancer. 2025 Jan 17;101642. doi.org/10.1016/j.ijgc.2025.101642

Courish MK, O’Brien MW, Maxwell SP, Mekari S, Kimmerly DS, Theou O. Relationship between frailty and executive function by age and sex in the Canadian Longitudinal Study on Aging. Geroscience. 2024 Jul 17. doi: 10.1007/s11357-024-01256-3. Epub ahead of print. PMID: 39014131.

Mah JC, Theou O, Perez-Zepeda MU, Penwarden JL, Godin J, Rockwood K, Andrew MK. A standard procedure for constructing a multi-level social vulnerability index using CLSA and SOS data as working examples. PLoS One. 2024 Dec 13;19(12):e0315474. doi: 10.1371/journal.pone.0315474. PMID: 39671368; PMCID: PMC11642991.

Courish MK, O’Brien MW, Maxwell SP, Mekari S, Kimmerly DS, Theou O. Relationship between frailty and executive function by age and sex in the Canadian Longitudinal Study on Aging. Geroscience. 2024 Jul 17. doi: 10.1007/s11357-024-01256-3. Epub ahead of print. PMID: 39014131.

O’Brien MW, Theou O. The Relation Between Frailty and Hypertension is Partially Mediated by Physical Activity Among Males and Females in the Canadian Longitudinal Study on Aging. Am J Physiol Heart Circ Physiol. 2024 May 17. doi: 10.1152/ajpheart.00179.2024. Epub ahead of print. PMID: 38758123.