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Canadian Longitudinal Study on Aging (CLSA)
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Approved Projects

CLSA approved projects encompass a broad spectrum of research topics and questions aimed at comprehensively understanding the aging process and its impact on health and well-being.

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Examining intersections of biographies & biologies: diversity & outcomes of people with multiple sclerosis in Canada (iBio2Div-MS)

Each person’s experience with multiple sclerosis (MS) differs and is likely due to a...

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Equity-focused, sex-aware early predictors of dementia by investigating novel multimodal features in the Canadian Longitudinal Study on Aging

Dementia is a growing health concern, affecting hundreds of thousands of Canadians. There is...

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The genetic prediction and classification of adult-onset type 1 diabetes using polygenic scores

Adult-onset type 1 diabetes (T1D) is a diagnostic challenge which can lead to misdiagnosis...

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Exploring long-term emotional and cognitive deficits in older adults with remote mild traumatic brain injury

Past research suggests there can be long-term consequences of a past concussion, such as...

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The relation between greenspace exposure and mental health

Exposure to greenspaces in urban areas has been linked to better mental health and...

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Understanding the characteristics of older adult volunteers sustainability

All community programs depend on volunteers, and anyone can be a volunteer. Seniors represent...

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Migraine and its relationship to cognitive function, hormonal factors, vascular disease and dementia in an aging population, an analysis of the prospective cohort longitudinal CLSA study

It is unclear whether individuals with migraine experience greater cognitive decline or higher dementia...

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Subjective and biological aging: Examining the association between perceived healthy aging and epigenetic age acceleration in a Canadian cohort

This study investigates the association between biological aging (as estimated by DNA methylation) and...

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Development of an equitable AI screening tool for ophthalmic and systemic diseases using retinal imaging and longitudinal cohort data

Vision loss and chronic systemic diseases are major public health concerns, particularly as the...

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The epigenetics of chronic liver disease

Steatotic liver disease (SLD), previously known as fatty liver disease, is the most common...

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Multi-organ functional ageing in the CLSA: Longitudinal phenotypes, omics, and mortality

We age in different ways. Some people lose strength or walking speed quickly; others...

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Multi-omics integrated analysis of obesity-related osteoarthritis

People who carry excess body weight have a much higher risk of developing osteoarthritis...

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