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Publications

Scientific publications using Canadian Longitudinal Study on Aging (CLSA) data.

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Casual effects of genetically determined blood metabolites on asthma: a bidirectional Mendelian randomization study

Lin L, Wu Z, Zhong A, Luo H, Xu W, Luo W. Causal effects of genetically determined blood metabolites on asthma: a bidirectional Mendelian randomization study. J Asthma. 2024 Aug 1:1-11. doi: 10.1080/02770903.2024.2380515. Epub ahead of print. PMID: 39087774.

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Genomic Analysis Identifies Risk Factors in Restless Legs Syndrome

Akçimen F, Chia R, Saez-Atienzar S, Ruffo P, Rasheed M, Ross JP, Liao C, Ray A, Dion PA, Scholz SW, Rouleau GA, Traynor BJ. Genomic Analysis Identifies Risk Factors in Restless Legs Syndrome. Ann Neurol. 2024 Jul 30. doi: 10.1002/ana.27040. Epub ahead of print. PMID: 39078117.

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Casual relationships between immune cells, inflammatory factors, serum metabolites, and hepatic cancer: A two-sample Mendelian randomization study

Chen H, Yang R, Zhang J, Tang J, Yu X, Zhou W, Li K, Peng W, Zeng P. Casual relationships between immune cells, inflammatory factors, serum metabolites and hepatic cancer: A two-sample Mendelian randomization study. Heliyon. 2024 Jul 23

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Role of blood metabolites in mediating the effect of gut microbiome on the mutated-RAS/BRAF metastatic colorectal cancer-specific survival

Xiang Y, Zhang C, Wang J, Cheng Y, Wang K, Wang L, Tong Y, Yan D. Role of blood metabolites in mediating the effect of gut microbiome on the mutated-RAS/BRAF metastatic colorectal cancer-specific survival. Int J Colorectal Dis. 2024 Jul 24;39(1):116. doi: 10.1007/s00384-024-04686-9. PMID: 39046546; PMCID: PMC11269474.

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Mediating role of chiro-inositol metabolites on the effects of HLA-DR-expressing CD14 + monocytes in inflammatory bowel disease

Zhang L, Shen P, Ge W, Liao W, Luo Q, Li C, Zhan C, Yuan X, Zhang X, Yan X. Mediating role of chiro-inositol metabolites on the effects of HLA-DR-expressing CD14 + monocytes in inflammatory bowel disease. BMC Gastroenterol. 2024 Jun 17;24(1):200. doi: 10.1186/s12876-024-03271-2. PMID: 38886630; PMCID: PMC11181584.

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Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression

Zhukovsky P, Tio ES, Coughlan G, Bennett DA, Wang Y, Hohman TJ, Pizzagalli DA, Mulsant BH, Voineskos AN, Felsky D. Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression. Nat Commun. 2024 Jun 18;15(1):5207. doi: 10.1038/s41467-024-49430-7. PMID: 38890310; PMCID: PMC11189393.

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Metabolic gene function discovery platform GeneMAP identifies SLC25A48 as necessary for mitochondrial choline import

Khan A, Unlu G, Lin P, Liu Y, Kilic E, Kenny TC, Birsoy K, Gamazon ER. Metabolic gene function discovery platform GeneMAP identifies SLC25A48 as necessary for mitochondrial choline import. Nat Genet. 2024 Jul 8. doi: 10.1038/s41588-024-01827-2. Epub ahead of print. PMID: 38977856.

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Causal relationships of gut microbiota, plasma metabolites, and metabolite ratios with diffuse large B-cell lymphoma: a Mendelian randomization study

Qian J, Zheng W, Fang J, Cheng S, Zhang Y, Zhuang X, Song C. Causal relationships of gut microbiota, plasma metabolites, and metabolite ratios with diffuse large B-cell lymphoma: a Mendelian randomization study. Front Microbiol. 2024 May 27;15:1356437. doi: 10.3389/fmicb.2024.1356437. PMID: 38860219; PMCID: PMC11163048.

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Exploring the Mediation Effect of Metabolite Levels on the Association Between Gut Microbiota and HCC: A two-step, two-sample bidirectional Mendelian Randomization

Xu B, Zhu L, Hu P, Yao W, Ke M, Zhu Z. Exploring the Mediation Effect of Metabolite Levels on the Association Between Gut Microbiota and HCC: A two-step, two-sample bidirectional Mendelian Randomization. J Cancer. 2024 May 30;15(12):3975-3983. doi: 10.7150/jca.96579. PMID: 38911378; PMCID: PMC11190768.

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A standard procedure for constructing a multi-level social vulnerability index using CLSA and SOS data as working examples

Mah JC, Theou O, Perez-Zepeda MU, Penwarden JL, Godin J, Rockwood K, Andrew MK. A standard procedure for constructing a multi-level social vulnerability index using CLSA and SOS data as working examples. PLoS One. 2024 Dec 13;19(12):e0315474. doi: 10.1371/journal.pone.0315474. PMID: 39671368; PMCID: PMC11642991.

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Adverse changes in close social ties in aging women and men: A population-based longitudinal study of the CLSA (2011-2021)

Ceolin G, Veenstra G, Khan NA, Madani Civi R, Mehranfar S, Conklin AI. Adverse changes in close social ties in aging women and men: A population-based longitudinal study of the CLSA (2011-2021). Arch Gerontol Geriatr. 2025 Mar;130:105720. doi: 10.1016/j.archger.2024.105720. Epub 2024 Dec 6. PMID: 39675164.

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Typology of Social Participation and Network and Health in Older Adults: Results From the Canadian Longitudinal Study on Aging

Deslauriers V, Levasseur M. Typology of Social Participation and Network and Health in Older Adults: Results From the Canadian Longitudinal Study on Aging. J Aging Health. 2025 Jan 9:8982643241311632. doi: 10.1177/08982643241311632. Epub ahead of print. PMID: 39787320.

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The CLSA data are currently available to approved public sector researchers in Canada and elsewhere. Learn more about eligibility and how to apply for access.

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