GWAS Summary Data

Li ZY, Li HL, Wang J, Shen QM, Zou YX, Yang DN, Tan YT, Xiang YB. Metabolomic insights into associations between adiposity markers and liver cancer risk: Results from a prospective cohort study and Mendelian randomization analysis. PLoS Med. 2026 Feb 2;23(2):e1004910. doi: 10.1371/journal.pmed.1004910. PMID: 41628182; PMCID: PMC12863527.

Zhou X, Fang YX, Zhang DW, Ma LY, Yao MM. Causal associations between 1400 circulating metabolites and spontaneous abortion: A bidirectional 2-sample Mendelian randomization study. Medicine (Baltimore). 2025 Nov 21;104(47):e45981. doi: 10.1097/MD.0000000000045981. PMID: 41305730; PMCID: PMC12643647.

Shi H, Peng Q. Role of metabolites in mediating the effect of gut microbiota on Crohn disease: A two-step Mendelian randomization (MR) study. Medicine (Baltimore). 2025 Nov 28;104(48):e46253. doi: 10.1097/MD.0000000000046253. PMID: 41327678; PMCID: PMC12662486.

Cui Q, Zhou B, Feng Y, Huang Q. 1400 plasma metabolites and Sjögren’s syndrome: a Mendelian randomization analysis. Clin Rheumatol. 2025 Dec 3. doi: 10.1007/s10067-025-07799-w. Epub ahead of print. PMID: 41335288.

Liu L, Liu B, Liao M, Zeng B, Qin L, Li M. Causal association of circulating metabolites with female infertility: a bidirectional mendelian randomization analysis. Metabolomics. 2025 Oct 16;21(6):149. doi: 10.1007/s11306-025-02357-6. PMID: 41102584.

Khan A, Yen FS, Unlu G, DelGaudio NL, Erdal R, Xiao M, Wangdu K, Cho K, Gamazon ER, Patti GJ, Birsoy K. Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis. Cell Metab. 2025 Oct 10:S1550-4131(25)00434-6. doi: 10.1016/j.cmet.2025.09.015. Epub ahead of print. PMID: 41075780.

Zhou J, Fu Z, Gao Y, An C, Zhang Z, Zhong X, Tian L, Yang X, Zhang J, Zhang Q, Wang D, Li N. Gut Microbiotas, Plasma Metabolites, and Autism Spectrum Disorder: A Bidirectional Mendelian Randomization Analysis. Pathogens. 2025 Nov 10;14(11):1137. doi: 10.3390/pathogens14111137. PMID: 41305374; PMCID: PMC12655273.

Zhang YW, Zhao SS, Li XY, Liu HZ. Blood metabolites mediate gut microbiota effects on depression: A Mendelian randomization study. J Affect Disord. 2025 Nov 4;394(Pt B):120478. doi: 10.1016/j.jad.2025.120478. Epub ahead of print. PMID: 41197911.

Zhao M, Li T, Shen H, Baranova A, Chandhoke V, Zhang F. Bidirectional Causal Associations Between Plasma Metabolites and Parkinson’s Disease. Mol Neurobiol. 2025 Nov 12;63(1):30. doi: 10.1007/s12035-025-05306-5. PMID: 41222837.

Tuo L, Yan LT, Liu Y, Wang SQ, Yang XX, An X. Genetically instrumented circulating metabolites and hepatobiliary cancer risk: A multi-tiered Mendelian randomization and functional interrogation. Front Oncol. 2025 Oct 27;15:1680865. doi: 10.3389/fonc.2025.1680865. PMID: 41220933; PMCID: PMC12597744.

Liu Z, Kuang L, Zhou X, Zhao J, Chen Q, Yin H, Liu X, Liu D, Wu S, Wu L. Effect of the plasma lipidome, immune cells, inflammatory proteins, gut microbiota, and plasma metabolites on Alzheimer’s Disease: A two-sample Mendelian randomized study and mediation analysis. Brain Res. 2025 Oct 26;1869:150009. doi: 10.1016/j.brainres.2025.150009. Epub ahead of print. PMID: 41151745.

Zheng X, Shen W, Yin J. The relationship between gut microbiota, plasma metabolites, and iron deficiency anemia in European populations: a three-sample Mendelian randomization analysis. Hematology. 2025 Dec;30(1):2549962. doi: 10.1080/16078454.2025.2549962. Epub 2025 Oct 4. PMID: 41045077.