A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases

Chechi K, Chakaroun R, Myridakis A, Forslund-Startceva SK, Fromentin S, Nielsen T, Aron-Wisneswky J, Belda E, Prifti E, Lassen PB, Falony G, Vieira-Silva S, Chilloux J, Sonomura K, Hoyles L, Martinez-Gili L, Pallotti F, Andrikopoulos P, Puig-Castellví F, Tapia RP, Castro-Dionicio I, Roume H, Pons N, Le Chatelier E, Quinquis B, Galleron N, Berland M, Olanipekun MT, Jia M, Manolias A, Holmes B, Adriouch S, Blüher M, Coelho LP, Da Silva K, Galan P, Ji B, Neves AL, Rouault C, Salem JE, Tremaroli V, Hansen TH, Søndertoft NB, Lewinter C, Pedersen HK; MetaCardis Consortium; Mark PD, Goetze JP, Køber L, Vestergaard H, Hansen T, Zucker JD, Sato TA, Hercberg S, Bäckhed F, Letunic I, Oppert JM, Nielsen J, Raes J, Tzoulaki I, Dehghan A, Zuber V, Bouzigon E, Lathrop M, Raina P, Froguel P, Matsuda F, Demenais F, Gauguier D, Stumvoll M, Bork P, Pedersen O, Ehrlich SD, Clément K, Dumas ME. A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases. Nat Commun. 2026 Mar 5. doi: 10.1038/s41467-026-69405-0. Epub ahead of print. PMID: 41786749.

Inflammatory cytokines mediate thoracic aortic aneurysm formation via plasma metabolites: A two-step Mendelian randomization and single cell sequencing-based investigation

Liu Y, Tang R, Fang Y, Tian F, Gu T. Inflammatory cytokines mediate thoracic aortic aneurysm formation via plasma metabolites: A two-step Mendelian randomization and single cell sequencing-based investigation. Medicine (Baltimore). 2026 Feb 6;105(6):e47561. doi: 10.1097/MD.0000000000047561. PMID: 41650052; PMCID: PMC12885723.

Gut microbiota in combination with blood metabolites and inflammatory cytokines reveals characteristics of hypertrophic cardiomyopathy: a Mendelian randomization study

Zhang, Yin1,2,3,4,5; Yang, Wenlong1,2,3,4,5; A, Jixiang1,2,3,4,5; Wu, Chunyu1,2,3,4,5; Liu, Xiaoyan1,2,3,4,5; Qian, Juying1,2,3,4,5; Zhang, Shuning1,2,3,4,5,*. Gut microbiota in combination with blood metabolites and inflammatory cytokines reveals characteristics of hypertrophic cardiomyopathy: a Mendelian randomization study. Cardiology Plus ():10.1097/CP9.0000000000000126, September 03, 2025. | DOI: 10.1097/CP9.0000000000000126

The role of sex and systemic inflammation in the development of cardiovascular disease in osteoarthritis: A population-based cohort study using the CLSA

Perruccio AV, Kral C, Yip C, Eder L, Power JD, Canizares M, Wilfong JM, Heckman G, Badley E. The role of sex and systemic inflammation in the development of cardiovascular disease in osteoarthritis: A population-based cohort study using the CLSA. Semin Arthritis Rheum. 2025 Aug 5;74:152804. doi: 10.1016/j.semarthrit.2025.152804. Epub ahead of print. PMID: 40780109.

Weight Change and Risk of Atherosclerosis Measured by Carotid Intima-Media Thickness (cIMT) from a Prospective Cohort-Analysis of the First-Wave Follow-Up Data of the Canadian Longitudinal Study on Aging (CLSA)

Liu J, Sze NSK, Narushima M, O’Leary D. Weight Change and Risk of Atherosclerosis Measured by Carotid Intima-Media Thickness (cIMT) from a Prospective Cohort-Analysis of the First-Wave Follow-Up Data of the Canadian Longitudinal Study on Aging (CLSA). J Cardiovasc Dev Dis. 2023 Oct 19;10(10):435. doi: 10.3390/jcdd10100435. Erratum in: J Cardiovasc Dev Dis. 2024 Jun 28;11(7):196. doi: 10.3390/jcdd11070196. PMID: 37887882; PMCID: PMC10607020.