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Publications

Scientific publications using Canadian Longitudinal Study on Aging (CLSA) data.

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Causality of multiple serum metabolties on emotional liability: A two-sample Mendelian randomization study

Xiao Z, Xu J, Li Z, Chen Z, Xu Z, Li Y, Du P, Wang C. Causality of multiple serum metabolites on emotional lability: A two-sample Mendelian randomization study. J Affect Disord. 2024 Sep 20;368:704-710. doi: 10.1016/j.jad.2024.09.130. Epub ahead of print. PMID: 39307429.

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Dissecting casual relationships between immune cells, blood metabolites, and aoritc dissection: A mediation Mendelian randomization study

Li A, Feng Z, Fu S, Ma Z, Zhang H, Zhao Z. Dissecting causal relationships between immune cells, blood metabolites, and aortic dissection: A mediation Mendelian randomization study. Int J Cardiol Heart Vasc. 2024 Oct 15;55:101530. doi: 10.1016/j.ijcha.2024.101530. PMID: 39483148; PMCID: PMC11525623.

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Causal effects of genetically determined metabolites and metabolite ratios on esophageal diseases: a two-sample mendelian randomization study

Yang H, Wang Y, Zhao Y, Cao L, Chen C, Yu W. Causal effects of genetically determined metabolites and metabolite ratios on esophageal diseases: a two-sample Mendelian randomization study. BMC Gastroenterol. 2024 Sep 14;24(1):310. doi: 10.1186/s12876-024-03411-8. PMID: 39271994; PMCID: PMC11401347.

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Causal relationship between plasma metabolites and carpal tunnel syndrome risk: evidence from a mendelian randomiztion study

Wu W, Fan D, Zheng C, Que B, Lian QQ, Chen Y, Qiu R. Causal relationship between plasma metabolites and carpal tunnel syndrome risk: evidence from a mendelian randomization study. Front Mol Biosci. 2024 Oct 3;11:1431329. doi: 10.3389/fmolb.2024.1431329. PMID: 39421691; PMCID: PMC11484071.

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Associations between human blood metabolome and risk of myocarditis: a Mendelian randomization study

Wang Z, Tian H, Wang J. Association between human blood metabolome and risk of myocarditis: a mendelian randomization study. Sci Rep. 2024 Nov 3;14(1):26494. doi: 10.1038/s41598-024-78359-6. PMID: 39489852; PMCID: PMC11532538.

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Blood metabolites as predictors of skin cancer risk: a comprehensive analysis

Wu K, He Y, Hua A, Yao Y. Blood metabolites as predictors of skin cancer risk: a comprehensive analysis. Postępy Higieny i Medycyny Doświadczalnej. 2024 Aug 18;78(1). DOI: https://doi.org/10.2478/ahem-2004-0007

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Assessing the casual relationship between metabolic biomarkers and coronary artery disease by Mendelian randomization studies

Yang K, Li J, Hui X, Wang W, Liu Y. Assessing the causal relationship between metabolic biomarkers and coronary artery disease by Mendelian randomization studies. Sci Rep. 2024 Aug 16;14(1):19034. doi: 10.1038/s41598-024-69879-2. PMID: 39152174; PMCID: PMC11329738.

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Multi-omics insight into the metabolic and cellular characteristics in the pathogenesis of hypothyroidism

Zheng S, Liu L, Liang K, Yan J, Meng D, Liu Z, Tian S, Shan Y. Multi-omics insight into the metabolic and cellular characteristics in the pathogenesis of hypothyroidism. Commun Biol. 2024 Aug 14;7(1):990. doi: 10.1038/s42003-024-06680-x. PMID: 39143378; PMCID: PMC11324791.

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Causality of genetic determined metabolites and metabolic pathways on osteoarthritis: a two-sample mendelian randomization study

Gu Y, Jin Q, Hu J, Wang X, Yu W, Wang Z, Wang C, Liu Y, Chen Y, Yuan W. Causality of genetically determined metabolites and metabolic pathways on osteoarthritis: a two-sample mendelian randomization study. J Transl Med. 2023 May 31;21(1):357. doi: 10.1186/s12967-023-04165-9. PMID: 37259122; PMCID: PMC10230782.

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Explore the genetic exposure to alopecia areata

Peng S, Yang Y, Man Y, Long D, Wang L, Li K, Liu P. Explore the genetic exposure to alopecia areata. Skin Res Technol. 2024 Aug;30(8):e13874. doi: 10.1111/srt.13874. PMID: 39086160; PMCID: PMC11291861.

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Casual effects of genetically determined blood metabolites on asthma: a bidirectional Mendelian randomization study

Lin L, Wu Z, Zhong A, Luo H, Xu W, Luo W. Causal effects of genetically determined blood metabolites on asthma: a bidirectional Mendelian randomization study. J Asthma. 2024 Aug 1:1-11. doi: 10.1080/02770903.2024.2380515. Epub ahead of print. PMID: 39087774.

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Genomic Analysis Identifies Risk Factors in Restless Legs Syndrome

Akçimen F, Chia R, Saez-Atienzar S, Ruffo P, Rasheed M, Ross JP, Liao C, Ray A, Dion PA, Scholz SW, Rouleau GA, Traynor BJ. Genomic Analysis Identifies Risk Factors in Restless Legs Syndrome. Ann Neurol. 2024 Jul 30. doi: 10.1002/ana.27040. Epub ahead of print. PMID: 39078117.

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Data Access

The CLSA data are currently available to approved public sector researchers in Canada and elsewhere. Learn more about eligibility and how to apply for access.

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