Métabolomique

Min, J., Vishnyakova, O., Brooks-Wilson, A. et al. Une nouvelle approche basée sur un réseau de neurones quantiles bayésiens parcimonieux et son application à la découverte de zones physiologiques optimales dans l'Étude longitudinale canadienne sur le vieillissement. GeroScience (2026). https://doi.org/10.1007/s11357-026-02280-1

Rafiq T, Ma J, Joshi D, Mayhew A, Griffith L, van den Heuvel E, Raina P. Dietary metabolomic determinants of frailty through inflammation in the Canadian Longitudinal Study on Aging. NPJ Aging. 2026 Mar 23. doi: 10.1038/s41514-026-00367-9. Epub ahead of print. PMID: 41872230.

Vishnyakova O, Min J, Leach S, Song X, Rockwood K, Brooks-Wilson A, Elliott LT. Metabolomic sweet spot clock predicts mortality and age-related diseases in the Canadian Longitudinal Study on Aging. Commun Med (Lond). 2026 Jan 10. doi: 10.1038/s43856-026-01375-2. Epub ahead of print. PMID: 41520049.

Rivera-Herrera AL, Rouleau M, Singbo MNU, Cuppens T, Prunier J, Droit A, Simonyan D, Guillemette C. Sexual dimorphism in metabolomic and phenotypic spectra of UGT deficiency: findings from the Canadian Longitudinal Study on Aging. Biol Sex Differ. 2025 Apr 22;16(1):26. doi: 10.1186/s13293-025-00708-5. PMID: 40264209; PMCID: PMC12013048.

Lelievre R, Rakesh M, Hysi PG, Little J, Freeman EE, Roy-Gagnon MH. Effect modification by sex of genetic associations of vitamin C related metabolites in the Canadian Longitudinal study on aging. Front Genet. 2024 Jul 31;15:1411931. doi: 10.3389/fgene.2024.1411931. PMID: 39144724; PMCID: PMC11322087.

Han X, Lains I, Li J, Li J, Chen Y, Yu B, Qi Q, Boerwinkle E, Kaplan R, Thyagarajan B, Daviglus M, Joslin CE, Cai J, Guasch-Ferré M, Tobias DK, Rimm E, Ascherio A, Costenbader K, Karlson E, Mucci L, Eliassen AH, Zeleznik O, Miller J, Vavvas DG, Kim IK, Silva R, Miller J, Hu F, Willett W, Lasky-Su J, Kraft P, Richards JB, MacGregor S, Husain D, Liang L. Integrating genetics and metabolomics from multi-ethnic and multi-fluid data reveals putative mechanisms for age-related macular degeneration. Cell Rep Med. 2023 Jul 18;4(7):101085. doi: 10.1016/j.xcrm.2023.101085. Epub 2023 Jun 21. PMID: 37348500; PMCID: PMC10394104.

Chen Y, Lu T, Pettersson-Kymmer U, Stewart ID, Butler-Laporte G, Nakanishi T, Cerani A, Liang KYH, Yoshiji S, Willett JDS, Su CY, Raina P, Greenwood CMT, Farjoun Y, Forgetta V, Langenberg C, Zhou S, Ohlsson C, Richards JB. Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases. Nat Genet. 2023 Jan;55(1):44-53. doi: 10.1038/s41588-022-01270-1. Epub 2023 Jan 12. PMID: 36635386.