Organismic resilience and post-COVID19 condition (PCC) in the CLSA

Project Summary

Persisting symptoms from COVID-19 can be predicted from a number of demographic and medical variables. However, little is known about how pre-infection biological hardiness factors might predict both the likelihood of experiencing persisting symptoms, and the rate of remission following the emergence of persisting symptoms (i.e., long COVID). Organismic resilience factors may be defined as epigenetic and central nervous system integrity indicator that measure the relative hardiness of an organism at the time of infection, on a biological level. We propose to use the CLSA to examine two general categories of resilience factors, which we believe have not yet been explored as predictors of COVID-19 symptom persistence: 1) epigenetic factors, and 2) cognitive function. Examining the predictive power of these two categories of indicators might provide new information to help identify those who may be more likely to experience persisting symptoms and benefit from early intervention.