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metabolomics

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Using multi-omics to predict chronic diseases outcomes

As people age, the risk od developing chronic diseases increases, including sarcopenia, cancer, obesity,...

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Diet and 6-year muscle and cognitive function trajectories in the Canadian Longitudinal Study on Aging: combining traditional and omics approaches

While heart health studies recommend eating more plant-based proteins, healthy aging studies highlight the...

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Multi-omics determinants underlying dementia susceptibility

Our research aims to protect people’s brains from dementia, a condition that causes memory...

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Using metabolomics to examine the association between diet, inflammation, and frailty in the Canadian Longitudinal Study on Aging (CLSA)

Frailty is a condition where our bodies become less resilient and struggle to cope...

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Identification of biomarkers of healthy aging

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Investigation of the aging process – a multi-omics approach

The rate of aging varies from individual to individual due to several factors, including...

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Biological dysregulation as a mechanism of unhealthy aging in older adults

Evidence suggests that a breakdown of the numerous biological systems that maintain good health...

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Degenerative protein modifications (DPMs) as molecular mediators connecting socio-demographic profile to the onset of age-related diseases

We have identified a set of degenerative protein modifications (DPMs) in patients’ tissues, resulting...

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Adverse childhood experiences, genomic influences, and acceleration of biological aging in middle-aged and older adults in the CLSA

Adverse childhood experiences (ACEs), including childhood exposure to abuse, neglect, and intimate partner violence...

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Canadian Longitudinal Study on Aging (CLSA): building a COVID-19 platform for research in Canada

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Identification of metabolic perturbations driving frailty in aging

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Association between mitochondrial DNA copy number and nuclear DNA methylation in cardiovascular disease and aging

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